Assessment IL-6, TGF-1, CRP, and Vit-D in Women With Uterine Fibroid

Abstract

Background: Uterine fibroids, also known as UFs, are the most common type of tumor that occurs in the female reproductive system. They affect a significant majority, around 70-80%, of women during their lifetime. Various factors that increase the incidence of Uterine Fibroids (UFs) have been found, including as vitamin D deficiency, inflammation, DNA repair deficit, and exposure to endocrine-disrupting chemicals (EDCs) in the environment. Objective: The purpose of this study to evaluated the level of IL-6, TGF-1, CRP, and Vit-D in women with uterine fibroid and study the relation these parameter with different ages. Materials and methods: 90 blood samples were collected and divided into (50) blood samples from women with uterine fibroids who received a diagnosis from a qualified medical specialist, and (40) blood samples from healthy women, whose ages ranged from (20-50). Assessment level of IL-6, TGF-1, CRP, and Vit-D have been done by using ELISA technique. Result: The results showed that there was no significant difference at the probability level (P>0.05) in the level of IL-6 in women with uterine fibroids, as it reached (44.9±4.4 pg/ml) when compared with healthy women (42.5±4.1 pg/ml). The results of this study showed a significant increase in the levels of both β-TGF and CRP in women with uterine fibroids at the probability level (P<0.05), reaching (2.870±0.760ng/ml, 62.9±6.4 pg/ml), respectively, when compared with Healthy women: As for Vit.D3, it showed a significant decrease in women with uterine fibroids at the probability level (P≤0.05), as it reached (5.92±1.87 ng/ml). Conclusion: This result concluded no differences in the level of IL-6 in women with uterine fibroids, while increase in the levels of both β-TGF and CRP . Furthermore, decrease level of Vit.D3.