Evaluation of CARD14(PSORS2) Gene Expression and IL-17 Serum Levels in Iraqi Patients with Psoriasis

Abstract

Background: Psoriasis is an inflammatory skin condition influenced by CARD14 gene dysregulation and polymorphisms, affecting NF-kB activation and cytokine production, with IL-17 playing a key role in its pathogenesis. Objective: To estimate serum IL-17 level and andCARD14(PSORS2) gene expression in Iraqi patients with Psoriasis. Materials and methods: the study involved 60 Psoriasis patients, and 60 healthy individuals admitted to a hospital between October 2023 and April 2024. Blood samples were collected, frozen for RT-PCR detection of CARD14 gene expression, and used for IL-17 serum levels by ELISA assay. Results: The study reveals a significant increase in IL-17 levels in psoriasis patients compared to healthy controls and a significant increase in PSORS-2 gene expression in psoriasis patients. Conclusion The study reveals a significant rise in IL-17 levels and PSORS-2 gene expression in psoriasis patients, suggesting that inflammation may be exacerbated by increased IL-17 production.