Seminal Malondialdehyde (MDA) Levels in Iraqi Males with Infertility: Exploring the Relationship with Body Mass Index (BMI)

Abstract

Background: The investigation of the relationship between BMI and MDA levels in male infertility is pivotal for comprehending the underlying mechanisms of infertility, pinpointing potential therapeutic targets, and devising personalized approaches to enhance fertility outcomes in men. Therefore, the primary objective of this study was to explore the correlation between MDA levels in seminal fluid and infertility in Iraqi males, along with its potential association with Body Mass Index (BMI). Methodology: Ninety males aged between twenty and forty-five were included in this cross-sectional study, all diagnosed with infertility by specialists at the infertility unit of Al-Batool Teaching Hospital between February 2022 and February 2023. The participants were categorized into three groups: the Normozoospermic Group (G1), the Asthenospermia Group (G2), and the Oligozoospermic Group (G3). Results: The distribution of age and BMI across the study groups (G1, G2, and G3) appeared to be uniform and not statistically significant, indicating more noticeable variations among the groups. However, waist circumference (WC) analysis suggested statistically significant differences among the groups, highlighting a non-negligible change in the frequency of obesity within the groups participating in the study. Between the study groups, there was no statistically significant difference in smoking habits. The seminal fluid MDA levels for G1 were significantly lower than those for G2 and G3. Additionally, Seminal plasma MDA levels and BMI showed a non-significant positive correlation. Conclusion: There is no correlation between BMI and MDA levels in male infertility.