Expression of Mgp in Calcification Leiomyoma uterus in postmenopausal women

Abstract

The Matrix Gla protein (MGP) is an extracellular polypeptide that can inhibit calcification in tissues that express Mgp molecules. An analysis employing histology and immunohistochemistry unveiled the general architecture and detected calcification within the fibroid. The study included gathering twelve samples after confirming through histological examination that the samples were affected by fibroid cysts. Each of these specimens was conserved in a 10% formalin solution. A histological examination was performed using two dyes, hematoxylin and eosin, to demonstrate the general histological organization. The Van Kossa stain was employed to detect the buildup of calcium anions in the tissue. Moreover, the immunohistochemical technique was used to detect the elevated expression of Mgp in the myofibers of leiomyoma-affected myometrium tissue.