Role of Resveratrol in Endotoxin Induced Uveitis: Literature Review

Abstract

Uveitis is defined by a range of diverse clinical manifestations of ocular disease and involves inflammation of the uveal tissue, which includes the iris, choroid and ciliary body. Uveitis is characterized by a variety of heterogeneous clinical manifestations of ocular diseases. Corticosteroid and immunosupressive medication are required for non-infectious uveitis since they can successfully control inflammation. This study investigates role of Resveratrol as a promosing treatment in endotoxin induced uveitis as a mimic human anterior uveitis. Resveratrol is acknowledged as an antioxidant polyphenol discovered in grape skin and red wine. Anti-inflammatory, anti-cancer, and antioxidant properties are only a few of Resveratrol many biological and medicinal potentials. Our study evaluated the role of Resveratrol in potential therapy of uveitis. Results demonstrate significant reduce of inflammatory cytokine and cells suggesting the potential therapeutic effect of Resveratrol.