Overdose of Anticoagulants in Patients Treated with Vitamin K Antagonists and Using Evening Primrose Oil: A Clinical Case and Theoretical Explanation

Abstract

This report presents the patient had an overdose of anticoagulants due to consuming evening primrose oil (EPO) while taking vitamin K antagonists (VKAs) in the patient has persistent atrial fibrillation, hypertension and heart valve problems. They were hospitalized, treated with vitamin K, and recovered. EPO has many health benefits, but it is necessary to avoid using EPO containing Gamma Linolenic Acid (GLA) fatty acid for patients who are using vitamin K antagonist (VKA) anticoagulants, as it can easily cause overdose anticoagulation, complications of bleeding, and endanger the patient's life.