Vanillin Pramipexole Schiff Base Metal Complexes: Synthesis, Characterization, And Dna Binding Studies

Abstract

In addition to being widely used in industry, Schiff bases and their complexes also exhibit a wide range of biological activities, such as antifungal, antibacterial, anti malarial, anti-proliferative, anti-inflammatory, antiviral, and antipyretic properties. These versatile compounds are created by condensation of an amino compound with carbonyl compounds. Numerous Schiff base complexes exhibit good catalytic activity in a variety of processes when moisture is present. Numerous studies on their use in homogeneous and heterogeneous catalysis have been published during the past few years. The study of these compounds' coordination behaviour has increased significantly as a result of the impact that some metals have on the biological activity of these substances as well as their inherent chemical interest as multidentate ligands. New chemotherapeutic Schiff bases and their metal complexes are currently garnering the attention of researchers. Medical chemists are now interested in developing novel chemotherapeutic Schiff bases and their metal complexes. The current study uses a modified version of Sand Mayer's approach to synthesise and characterise metal complexes of novel Schiff bases obtained from Pramipexole (4, 5, 6, 7-Tetrahydro-N6-propyl-2, 6-benzothiazolediamine) and Vanillin. Synthesized compounds were analysed using a variety of methods, including conductometric titrations, IR, 1HNMR, UV-visible, and UV-visible spectroscopy. According to infrared spectrum data, the core metal ion and ligand are coordinated by deprotonated phenolic oxygen and azomethine nitrogen. Additionally, the compounds were examined by the authors for DNA binding tests. These complexes were discovered to have significant binding capacities.