Correlation Of NAG, NGAL, and Oxidative Parameters For Patients With Diabetic Nephropathy

Abstract

Background: Diabetic nephropathy is a clinical syndrome that is present in diabetic mellitus patients and characterized by albuminuria {>200 or >300 mg\day}, a gradual glomerular filtration rate decline along with hypertension. Objective: Study the correlation between N_acetyl-ß-D-glucamindase and human neutrophil gelatinase-associated lipocalin and oxidative parameters in diabetic nephropathy patients compared with a control group and several variables by Explaining the results scientifically. Method: The blood sample was collected from forty-five diabetic nephropathy patients and forty-five controls from Merjin Medical Hospital and Al-Imam Al-Sadiq Hospital in Iraq to assess N-acetyl-β-D-glucosaminidase and human neutrophil gelatinase-associated lipocalin levels by used Enzyme-Linked immunosorbent Assay technicality (ELISA) and also to determine the oxidative parameters (total oxidant system, total antioxidant capacity, malondialdehyde and glutathione) by used spectrophotometer. Result: positive correlation for N-acetyl-β-D-glucosaminidase with total oxidant status and malondialdehyde where the correlation coefficient (r=0.893**, 0.809**) at respectively and negative correlation with total antioxidant capacity and glutathione where the (r=-0.851**, -0.465**) at respectively, and exact correlation for human neutrophil gelatinase-associated lipocalin with total oxidant status, malondialdhyde, total antioxidant capacity, glutathione. Conclusion: The assessment of NAG, NAGL, and oxidant parameters can provide crucial information for the early diagnosis, management, and therapy of these patients with diabetic nephropathy.