Evaluation of CD10 and E-cadherin as Biomarkers in Chronic Kidney Disease Progression at Al-Najaf Province/Iraq

Abstract

Chronic Kidney Disease (CKD) is when kidney function deteriorates over three months, resulting in a build-up of waste in the blood and tissues. Common causes of CKD include diabetes and hypertension. The study aims to investigate the association of ( E-cadherin, CD10) and other biomarkers in patients suffering from CKD and the possibility of using them as diagnostic criteria. The cohort of 96 patients with CKD and the control group of 88 healthy individuals comprised the current stud. The levels of CD10, E-cadherin, and other biochemicals were measured in the serum of the experimental group and the patients. The findings demonstrated that in contrast to healthy individuals, patients with CKD had significantly lower serum concentrations of E-cadherin (p<0.05), while there was no significant difference in CD10 levels between the patient and control groups (p>0.05). These results corroborate data indicating an essential role the E-cadherin marker may play in the development of chronic kidney disease.