Impact of Angiotensin II Receptor Levels in Serum and Follicular Fluid on ICSI Outcomes in Infertility Cases

Abstract

Male and female infertility are defined as a medical problems.Childless status syndrome is a condition when a couple has no success in conceiving a child, after 12 months of unprotected sex.In ovary, uterus and placenta, peptide receptors of the renin-angiotensin system are found along with angiotensin.The local function of renin-angiotensin system is observed not only in the ovary, but also in there.IVF experts put Intracytoplasmic Sperm Injection (ICSI) into the use of treating male-factor infertility of a severe degree.One sperm is brought into the mature cell by ICSI which is a way of injecting it directly.This study looks on the levels of the receptors of blood and follicular fluid Angiotensin II and investigates their influence on ICSI, which is one of the infertility treatments options.Designed the cross-sectional research, which involved 90 infertile women who had undergone the intra cytoplasmic sperm injection.The participants were divided by BMI into three groups: the normal range of BMI is 18.5-24.9, overweight falls within the range of 25-29.9, and obesity is defined as BMI of 30-34.9. An ELISA test in the private laboratories was carried out to measure angiotensin receptors in blood and follicular fluid on the day of oocyteBMI of the usually weighted women, the women were overweight and with obesity had significantly diverse mean BMIs.The age, time of infertility, and the type of infertility there was no substantial difference found between groups.The hormone levels were found not to be that different in reproductive-aged and obese-normal weight infertile girls as well as obese women.The study studies demonstrated that higher follicular fluid angiotensin II receptor concentrations were related well with intracytoplasmic sperm injection measures.This study has indeed revealed that all the IVF-ET patients involved in the research did have the angiotensin II receptors 1 in their blood and the follicular fluid.The follicular fluid turns out to have increased levels of receptors rather than the serum.Aetgenin Il receptors 1 blood and follicular fluids levels are in no way connected.The angeliotensin II recept1 (AT1/serum angiotensin II) levels in serum were not correlated to follicles.It is possible that high follicular angiotensin II receptor 1 fluid levels lead to conception, which may explain why the patient is now expecting a baby.There was a definite relationship happening in levels of Angiotensin II Receptor 1 and pregnancy.