Effect of phytosome based extract of oyster and button mushroom on liver function profile of streptozotocin induced diabetic Wistar rats Short Title: ANTIDIABETIC EFFECT OF MUSHROOM LOADED PHYTOSOMES

Abstract

Diabetesmellitus is a persistent, sometimes fatal illness that can impact many different organ systems, including the liver. The current study serves as the basis for evaluating the effects of phytosomes derived from mushroom extract (oyster and button mushroom)on liver functioning factors such SGPT,SGOT and Bilirubin as well as the glucose level in streptozocin (STZ) -induced rats with diabetes. According to the results, the groups treated with a combination of lactobacillus and mushroom extract (oyster and button mushroom) showed a substantial drop in blood sugar levels compared to the diabetic control group (P≤0.05).Similarly, the levels of glucose, SGPT, SGOT, and bilirubin(P≤ 0.05) significantly decreased after treatment with phytosomes of oyster mushrooms combined with Lactobacillus, as well as phytosomes of button mushrooms with Lactobacillus.Therefore, these can be considered effective alternatives for the treatment of diabetesmellitus alongside allopathic medications.