Local ozone therapy application methods in the surgical treatment of brain echinococcosis

Abstract

Echinococcosis of the brain is a severe parasitic disease that represents a significant medical problem in the Kyrgyz Republic, where there is an increase in the incidence, especially among children. The study aims to improve the results of neurosurgical treatment of patients with brain echinococcosis by using ozonated saline solution to treat residual cavities after the removal of parasitic cysts. The study included 34 patients who underwent surgery for brain echinococcosis at the Neurosurgery Clinic of the National Hospital under the Ministry of Health of the Kyrgyz Republic in the period from 2015 to 2022. During the operation, ozonated saline was used to fill and disinfect the remaining cavities. The results showed that the ozonated solution caused significant morphological changes in Echinococcal Protoscolexes, leading to the destruction of cellular components and loss of the parasites’ ability to replicate. Within a year after operation, 88.2% of patients had no recurrence of the disease. In addition, most patients reported a significant improvement in their health, and the absence of headaches and seizures, which indicates the high quality of the treatment and its positive impact on the quality of life. The assessment of side effects and complications showed that ozone therapy is a safe treatment method with minimal side effects. The present study confirms the high efficacy of ozonated saline in the surgical treatment of brain echinococcosis, opening new perspectives for the use of this method in medical practice and offering an effective means for treating residual cavities, which significantly reduces the risk of recurrence and improves clinical outcomes.