An analytical study to evaluate the levels of serum creatine kinase and serum magnesium in patients admitted with diagnosis of organophosphorus consumption.

Abstract

Introduction: Organophosphorus poisoning (OPP) is a serious health issue caused by the inhibition of acetylcholinesterase, leading to cholinergic toxicity. This study aimed to evaluate serum creatine kinase (CK) and magnesium levels as diagnostic and prognostic markers in OPP patients.
Methodology: A prospective observational study was conducted at Krishna Hospital from February 2022 to January 2024, including 75 patients diagnosed with acute OPP.
Observations: The mean age of patients was 36.44 years, with 66.67% males. Chlorpyriphos was the most common poison (81.33%). The mortality rate was 22.67%, with a significant association between CK and magnesium levels and patient outcomes. Mean CK levels were significantly higher in non-survivors (1388.71 IU/L) compared to survivors (712.10 IU/L) (p < 0.001), while mean magnesium levels were significantly lower in non-survivors (1.50 mg/dl) compared to survivors (1.82 mg/dl) (p < 0.001).
Conclusion: Serum CK and magnesium levels can serve as reliable prognostic markers for OPP severity and outcomes.