A STUDY OF NUCLEATED RED BLOOD CELLS IN CORD BLOOD OF NEONATES BORN WITH MECONIUMSTAINED AMNIOTIC FLUID WITH RESPIRATORY SYMPTOMS AND IN THOSE BORN WITH CLEAR AMNIOTIC FLUID

Abstract

Introduction: Meconium, a fetal secretion containing urine, hair, and vernix, is present in the fetal ileum within 10-16 weeks of gestation. It is the first stools a newborn passes and is the first symptom a newborn passes within 24 hours of birth. Meconium aspiration syndrome (MAS) is a life-threatening respiratory disease affecting some neonates born through meconium-stained amniotic fluid. Aims: The study aims to compare the number of NRBC/100WBC in neonates born with meconium-stained amniotic fluid with respiratory symptoms and those with clear amniotic fluid. Methodology: The study enrolled twelve newborns at Krishna Hospital, Karad, to compare hematological parameters. The study included term newborns, normal birth weight, and vaginal delivery. Exclusion criteria included pre-existing conditions. Results: The study compared gestational age, Hb%, birth weight, WBC count, and ESR between groups A, B, and C. No significant differences were found in NRBC count/100 WBC, ESR, mode of delivery, or respiratory symptoms. Discussion: Meconium stained amniotic fluid (MSAF) is a common issue in pregnancies, causing cardiovascular and inflammatory responses, pneumonitis, and pulmonary hypertension. As gestational age increases, the likelihood of developing MSAF increases. Conclusion: The study found that newborns with meconium aspiration syndrome and respiratory symptoms had higher neoplastic blood cell (NRBC) counts, indicating increased respiratory distress severity and potential markers of intrauterine hypoxia.