“EFFECT OF PERINATAL ASPHYXIA ON THYROID HORMONES AND THYROID STIMULATING HORMONE IN NEW BORNS”

Abstract

Introduction: Perinatal asphyxia, a major cause of early infant deaths in India, accounts for 30% of neonatal mortality globally. It is a significant contributor to death and morbidity, with severe birth asphyxia affecting 4.6% of neonates. Prenatal asphyxia outcomes are challenging to predict. Aims: The study investigates the effects of perinatal asphyxia on thyroid hormones and TSH levels in newborns and the correlation between Hypoxic Ischemic Encephalopathy severity. Methodology: The study compares thyroid hormone levels in 50 full-term newborns, 25 with birth asphyxia and 25 without, over 18 months in Krishna Vishwa Vidyapeeth, Karad, assessing gestational age, perinatal events, consent, and newborn examination. Results: The study explores the effects of perinatal asphyxia on thyroid hormones and stimulating hormone levels in newborns, revealing low incidence of meconium-stained liquor, hypoxic-ischemic encephalopathy, and thyroid hormone differences. Discussion: The study found mixed associations between birth weight and perinatal asphyxia, with vaginal delivery more common in non-asphyxiated neonates and LSCS more prevalent in asphyxiated newborns. Conclusion: Perinatal asphyxia affects neonatal health, leading to lower thyroid hormone levels, higher HIE stages, seizures, and meconium stained liquor. Early identification, monitoring, and comprehensive management are crucial.