COMPARISON OF INTRAPERITONEAL INSTILLATION OF ROPIVACAINE WITH DEXMEDETOMIDINE VS ROPIVACAINE WITH DEXMEDETOMIDINE AND TRAMADOL FOR POST-OP ANALGESIA FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY- RANDOMISED DOUBLE-BLIND CLINICAL STUDY

Abstract

Introduction: Post-surgery pain in laparoscopic cholecystectomy patients is often managed with NSAIDs and opioids, but their side effects limit their effectiveness. This study aims to optimize pain management strategies by comparing the effectiveness of ropivacaine, dexmedetomidine, and tramadol in reducing postoperative pain and improving surgical patient care. Aims: The study evaluates the post-operative analgesia efficacy of Ropivacaine plus Dexmedetomidine versus Ropivacaine with Dexmedetomidine and Tramadol in patients post-cholecystectomy surgery, focusing on VAS score and rescue time. Methodology: A randomized double-blind clinical study at Krishna Vishwa Vidyapeeth University in Maharashtra analyzed patients aged 18-60 with ASA grade 1 and 2 for laparoscopic cholecystectomy. The study included patients with ASA physical status 1 and 2, aged 18-65, and a body weight of 50 kg or more. Postoperative care involved continuous monitoring, pain assessment, and rescue analgesia. Results: The study found no significant differences in age, gender, weight, BMI, post-operative pain perception, rescue analgesia dose requirements, heart rates, diastolic blood pressure, or SPO2 levels between the RD and RDT groups. Discussion: The study found no significant association between age and clinical trials' outcomes. ASA status distribution was similar between RD and RDT groups. The ropivacaine and dexmedetomidine combination showed lower pain scores and prolonged analgesia. No significant difference in systolic blood pressure was found. Conclusion: The study indicates that incorporating tramadol into a combination of Ropivacaine and Dexmedetomidine significantly improves post-operative analgesia quality, duration, and rescue time, thereby enhancing patient comfort and satisfaction.