STUDY OF TROPONIN I LEVELS IN EVALUATION OF CARDIOVASCULAR STATUS OF FULL-TERM BIRTH ASPHYXIATED NEONATES

Abstract

Introduction: Birth asphyxia, a prolonged imbalance between oxygen demand and supply, accounts for 24% of neonatal deaths and 11% of fatalities in children under 5. Perinatal asphyxia leads to multiple organ dysfunction, including myocardial involvement, which can affect outcomes. Elevated troponin I levels in asphyxiated newborns are crucial biomarkers for detecting cardiac injury, and this study aims to determine their relationship with hypoxic-ischemic encephalopathy stages. Aims: The study explores the link between troponin I levels, cardiovascular status, disease severity, and mortality in asphyxiated full-term neonates, examining the relationship between these factors. Methodology: The study, a cross-sectional observational observational study, examined the prevalence of birth asphyxia in inborn neonates at Krishna Hospital, Karad, focusing on factors such as gender, birth weight, delivery mode, neurological involvement, and maternal risk factors. Results: The study analyzed the prevalence of ovarian cancer in women and men, with a majority of cases being females. The most common cause was fetal distress. The study found that asphyxiated subjects had higher troponin I values, and a higher percentage of subjects had neurological involvement. The majority of cases experienced convulsions or comatose state. Discussion: A study found no significant association between pH values, APGAR score, and cord blood ABG in newborn babies, but found meconium-stained liquor more common in asphyxiated neonates. Conclusion: Birth asphyxiated individuals exhibited higher cardiac troponin I levels, linked to increased mortality, cardiovascular, and neurological issues, potentially serving as a biomarker for these parameters.