Neuropharmacological Activities of Evolvulus alsinoides Plant Extract in Swiss Albino Rats

Abstract

The aim of the present study was to investigate the neuropharmacological (antidepressant) activities of Evolvulus alsinoides whole plant extract in swiss albino rats. Anti-depressant activities of the methanolic extract of Evolvulus alsinoides were assessed by behavioral tests like Forced Swimming Test (FST), Tail Suspension Test (TST), and Locomotor Activity Test in male Swiss albino rats. By measuring the levels of oxidative stress markers in the rat brain homogenates, including plasma nitrites, plasma corticosterone and catalase (CAT), reduced glutathione, malondialdehyde (MDA), and superoxide dismutase, we were also able to investigate the neuropharmacological activities. Methanolic extract of the Evolvulus alsinoides plant showed significant neuropharmacological activity in Swiss albino rats. In both TST and FST, they significantly reduced the immobility duration and demonstrated dose-dependent activity (p<0.001). It demonstrated much more activity than imipramine in FST at 400mg kg-1 (p<0.001). Compared to the control group, they demonstrated a statistically significant increase in swimming time (p < 0.001). According to our research, Evolvulus alsinoides exhibited significant antidepressant properties. It appears that the primary mechanism underlying this action is catecholamine reuptake inhibition.