Pharmacokinetics and Pharmacodynamicinteraction of amlodipine with Allium sativum in Hypertensive Rat Models

Abstract

Amlodipine and Allium Sativum are commonly used in conjunction to treat hypertension and hyperlipidemia. Investigating the pharmacological connection between amlodipine and Allium sativum is essential. Rat liver microsomes and the interaction between Allium Sativum and amlodipine were investigated in rodents. Six rats per group were used to examine the biological effects of amlodipine (1 mg/kg) in rats, irrespective of whether they had previously received Allium Sativum therapy (2 mg/kg). Rat liver microsomes were used to study amlodipine's metabolic equilibrium. The Cmax (26.19 ± 2.21 vs 17.80 ± 1.56 lg/L), AUC(0-t) (507.27 ± 60.23 versus 238.68 ± 45.59 lg/L), and t1/2 (14.69 ± 1.64 versus 11.43 ± 1.20 h) of amlodipine were all considerably increased by Allium Sativum (p < 0.05).
The half-life of amlodipine in rat liver microsomes rose from 34.23 ± 3.33 to 44.15 ± 4.12 minutes, indicating an improvement in metabolic stability. From 40.49 ± 3.26 to 31.39 ± 2.78 lL/min/mg protein, the intrinsic rate decreased. These results indicated that the combination of amlodipine and allium sativum may result in drug-drug interactions.
One possible mechanism is that Allium Sativum inhibits CYP3A4. Therefore, this interaction necessitates extra research to describe the effect in humans as well as special attention in theclinic.