Developing and Testing iron oxide Encapsulated by Chitosan-Loaded the medication Capecitabine Nanomaterials for Breast carcinoma Management in Vitro

Abstract

Biodegradable, biocompatible, and bio adhesive nanoparticulate carriers offer a wide range of practical uses in the delivery of medicinal compounds. The goal of the current work was to create and optimize Chitosan-Fe3O4 nanoparticles loaded with capecitabine and investigate the in-vitro assessment using the sigma dialysis method. Ionic gelation was used to create batches of capecitabine-loaded chitosan-Fe3O4 nanoparticles with varyingratios of medication to polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6). The drug content of nanoparticles rises with an increase in polymer concentration. When the drug to polymer ratio was F3 (1:3), the entrapment efficiency was 60.12%. The in-vitro release for 12 hours was 65.20%. Capecitabine is derived fromFe3O4-chitosan nanoparticles Particles with sizes ranging from 100 to 500 nm and a distinct spherical structure are visible in the SEM image. The functional groups found in formulas that don't alter properties are represented by FTIR investigations. During the eight weeks of storage, samples housed in a refrigerator demonstrated greater stability than samples held in other circumstances.