ANTIFUNGAL ACTIVITY OF BIOGENIC METAL SALT COMPLEXES (MnCL2, ZnSO4) WITH AMINO ACIDS

Abstract

The antifungal activity of complexes formed between biogenic metal salts ( MnCl₂ and ZnSO₄) and amino acids (L-tryptophan) has garnered significant attention due to the combined effects of metal ions and amino acids on biological activity. The interaction between metal ions and amino acids can influence the stability and bioactivity of the resulting complexes, including their potential to inhibit fungal growth. Metal complexes may act synergistically with other antifungal agents, enhancing their efficacy. This synergy can arise from complementary mechanisms of action, such as disrupting fungal cell integrity while concurrently inhibiting key enzymatic functions.The findings show that the zinc and manganese complexes exhibited superior antibacterial activity compared to the tested standard, while the complex with tryptophan (Trp) exhibited satisfactory antifungal properties. This suggests that the complexes could potentially serve as novel active ingredients in dermatological products due to their promising antimicrobial effects. Further research and development could investigate their efficacy and safety in practical applications, particularly in the treatment of skin infections or as part of skin care formulations.