Development and Evaluation of Gastroretentive Drug Delivery System of BCS Class-II Drug for an Peptic Ulcer

Abstract

The purpose of this research was to prepare a gasteroretentive floating microcapsule of peptic ulcer drug which is expected to deliver the drug in controlled manner with reduced frequency of drug administration, improve patient compliance and bioavailability of peptic ulcer drug. the half-life of most of the peptic ulcer drug is less than 3 hours so controlled release formulation of peptic ulcer drug would increase the length of time release in which peptic ulcer drug achieves an effective concentration in the GIT. This study mainly deals in the design of a formulation which produces time controlled prolonged drug release and to enhance the bioavailability of the drug to about 90 0/0 and also to reduce the dosing interval of drug. the formulation will be characterized for drug content, particle size distribution, zeta potential, in vitro and in vivo drug release, stability study will improve the bioavailability of the drug.