EFFICACY AND IMPACT OF L-ARGININE IN TREATING OLIGOHYDRAMNIOS DURING THE SECOND TRIMESTER: AN AMBISPECTIVE OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL

Abstract

Oligohydramnios, which causes feto-maternal morbidity and mortality, is becoming more common throughout the world and is a serious public health concern. Amniotic fluid, which is high in water during the early phases of pregnancy, is the fluid that makes up the amniotic sac. In subsequent stages, nutrients, hormones, antibodies, and the baby's urine progressively begin to show up. It protects against bacteriostatic infections and provides the growing fetus with its primary source of nutrients. An Ambispective observational study was conducted for 6 months in a tertiary care hospital, involving 143 patients with Oligohydramnios . Data was collected through a data collection form and stress was analyzed by using Perceived stress scale.
The majority of participants have seen a rise in AFI of 2 cm following L-arginine use. There is more proof that stress can lead to oligohydramnios. Stress (27.27%) is the primary risk factor in the majority of individuals. Our study's results indicate that L-arginine has a potential effect on pregnant women with oligohydramnios who are in their second trimester. Amniotic Fluid Index (AFI) is higher as a result of the L-arginine 5g sachets' ingestion. Stress is the main risk factor for oligohydramnios in the majority of females. Our analysis suggests that people receiving L-arginine TID with appropriate adherence have increased amniotic fluid, however the clinical manifestations differ between studies.