Mucuna Pruriens Seeds Extract Loaded Phytosomes for The Effective Treatment of Parkinson’s Disease

Abstract

One phytoconstituent derived from Mucuna pruriens (legumes) is levodopa. This medication's oral usage is limited by its high first-pass metabolism and low absorption. The goal of the present research was to develop a optimized Phytosomal drug delivery system with Mucuna pruriens seeds extract for better delivery. Various techniques, including solvent evaporation, salting out anti-solvent precipitation, direct egg yolk, and egg lipids methods, were used to create phytosomal formulations. Scanning electron microscopy, particle size, x-ray diffraction, and other techniques were used to characterize phytosomes. The most effective Phytosomes were those made via the antisolvent precipitation approach. In this investigation, a 32-randomized complete factorial design was employed. Batch F4 had an entrapment efficiency of 70%, a particle size of 15 (μg) and 60% CDR. For improving Parkinson's disease treatment, the optimized phytosomal formulation delivered via the nasal route would be the ideal option