Role of Biochemical Parameters on Hypertension in Pregnant Females

Abstract

Pregnancy is a physiological state that involves significant alterations in metabolic, biochemical, physiological, and hematological processes. Pregnancy-induced hypertension (PIH) includes a spectrum of disorders ranging from mild hypertension to severe multi-organ failure. This study aims to investigate the biochemical and demographic variables in pregnant women who are more than 20 weeks’ gestation. Additionally, it seeks to compare the biochemical parameters of patients with pregnancy-induced hypertension to those of normotensive subjects. The study comprised 160 participants, with 80 women classified as hypertensive and 80 as normotensive. Serum levels of calcium, uric acid, and thyroid-stimulating hormone (TSH) were assessed in both groups. Demographic and biochemical parameters were analyzed using the t-test, considering a p-value of <0.05 as statistically significant. The levels of serum calcium, uric acid, and TSH were measured using spectrophotometry and ELISA techniques. The results revealed a statistically significant reduction in serum calcium levels among hypertensive women compared to their normotensive counterparts. In contrast, the hypertensive group exhibited higher levels of uric acid and TSH relative to the normotensive group. Our findings indicate significant differences in serum calcium, uric acid, and TSH levels between the two groups. Although these factors may not directly influence the development of PIH, their interrelationship should not be overlooked. Further research into the underlying pathological mechanisms associated with PIH could improve diagnostic capabilities in future studies.