Formulation and evaluation of a polyherbal suspension using popular antioxidant plants from tribal belts of Kandhamal, Odisha

Abstract

The possibility of gastrointestinal problems, skin sensitivities, and in certain cases, an elevated risk of cancer, are the main drawbacks of long-term use of contemporary marketed antioxidant formulations. By using well-known antioxidant plants (like Cayratia trifolia, Sesbania grandiflora, Cordia dichotoma, and Teprosia purpurea) from tribal belts of Kandhamal, part of the eastern Ghat mountain range, and fenugreek mucilage as a natural suspending agent; our study seeks to develop and assess an appropriate polyherbal suspension that addresses the aforementioned problem. Eight batches (F1–F8) were made using varying concentrations of propylene glycol and natural suspending agent. Numerous criteria, including rate of flow, volume of accumulation/sediments, acidity/basicity, re-dispersibility, flow, effect of temperature, agglomeration/flocculation degree and viscosity; were examined to assess these suspensions. It was discovered that batches F6 and F7 have antioxidant qualities and were steady during our entire study period. It was noted that the viscosity of our formulation raised with increase in concentration of suspending agents, which decreases sedimentation and increases suspension stability. Folin Ciocalteu's reagent method, which measures the formulation's total phenolic contents, was used to study the antioxidant qualities.