Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

Abstract

Purpose: To evaluate the associations of optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer thickness (mGCIPLT) ; circumpapillary retinal nerve fiber layer thickness (cpRNFLT) ; optic nerve head (ONH) parameters with visual field (VF) sensitivity in advanced glaucoma
Methods: In this hospital based cross-sectional observational study , 43 eyes from 43 patients with advanced glaucoma were subjected to assess mGCIPLT, cpRNFLT, and ONH parameters (including the rim area, average cup-to-disc [C:D] ratio, and vertical C:D ratio) using Cirrus high-definition OCT, 24-2 and 10-2 VF sensitivity visual field tests using The Humphrey field analyzer (HFA) . Pearson correlation coefficients were used to analyze relationships between
OCT-derived parameters and VF parameters .
Results: The mGCIPLT and rim area were significantly posi¬tively correlated with the 24¬-2 VF MD , while the average and vertical C:D ratios were significantly negatively correlated with the 24-¬2 VF MD . Moderate correlations were observed between the mGCIPLT and ONH parameters and the 24¬-2 VF PSD. The correlations between the mGCIPLT and ONH parameters and the 24¬-2 VF VFI were also moderate . Moderate or strong correlations were observed between the mGCIPLT and ONH parameters and the 10¬-2 VF MD. The mGCIPLT and rim area were significantly pos¬itively correlated with the 10-¬2 VF MD , while the average and vertical C:D ratios were significantly negatively correlat¬ed with the 10-¬2 VF MD.
Conclusion: In conclusion, we found that mGCIPLT and ONH pa¬rameters were associated with the severity of VF damage and reflected functional damage better than cpRNFLT in advanced glaucoma. These results suggested that struc¬tural measurements of mGCIPLT and ONH parameters and functional measurement of the 10¬-2 VF may be useful for monitoring progression in advanced glaucoma.