Association of DVWA, MATN-3, and ADAMTS-14 Gene Polymorphisms with Knee Osteoarthritis Susceptibility: A Systematic Review and Meta-Analysis

Abstract

Background:Knee osteoarthritis (KOA) is a common degenerative joint disorder characterized by the progressive deterioration of articular cartilage. Studies have suggested that DVWA (rs7639618) with KOA susceptibility. However, the results remain inconclusive.Aim:This meta-analysis aims to assess the association between the DVWA (rs7639618) gene and its potential role in susceptibility to KOA. Methodology:Meta-analysis was conducted in accordance with the PRISMA guidelines. Literature search was conducted up to January 2024 across several databases, including Science Direct, Pub Med, Web of Science, and Google Scholar, to identify appropriate case-control studies. Statistical analyses were performed using Metagenyo and Review Manager 5.4 software. Sub group analysis was performed based on ethnicity. Publication bias was analyzed using funnel plot and eggers test. Results:The meta-analysis included 13 studies with 14041 participants. The results revealed no statistical significant associations between any of the tested genetic models: allelic, recessive, dominant, or over dominant. Sub group analysis results revealed both Asian and Caucasian populations were not risk with KOA. Publication bias was analyzed by funnel plot and results revealed so significant bias.
Conclusion:Future large-scale well-controlled studies are necessary to validate present findings and to provide a clearer understanding of how DVWA, MATN-3, and ADAMTS14 gene variants contribute to KOA. A better understanding of the genetic factors involved in KOA can lead to the development of targeted treatments and personalized management strategies for this debilitating condition.