The Interdependence of nonstructural proteins (NS1) in development of dengue fever and its effects on the haematological and immune systems in the South east Asian population

Abstract

Dengue fever is known as a viral infection that is spread by several vectors, the most important of which is the Aedes mosquito (such as Aedes aegypti and Aedes albopictus) and is caused by the dengue virus (RNA virus) of the family Flaviviridae. DENV-1, DENV-2, DENV-3, and DENV-4 has main four serotype of the virus, In 2013 the fifth serotype was discovered DENN-5. Countries allocate a large budget to combat the disease because the disease has become a major public health problem, especially in recent decades due to the worsening of cases and the increase in numbers, especially among the population of Southeast Asia. The purpose of this review is to provide an overview of the dengue virus and investigate the role of non-structural proteins, in increasing disease severity. This study dealt with the damage resulting from the increase in disease severity on the hematological and immune systems, and explored the possibility that genetic factors contribute to the severity of the disease. In conclusion, there are differing opinions about the association of disease severity in dengue virus infection with non-structural proteins, but a significant role appears to exist for genetic factors in increasing the severity of the disease. due to the lack of focus on this type of research, the study recommends focusing on the role of NS1 )One of the non-structural proteins( in order to obtain exploratory results that contribute to reducing the severity of the disease or developing effective prevention methods against infection.