The miRNA Expression in Knee Osteoarthritis

Abstract

Background and Aim: Osteoarthritis (OA) is a degenerative condition of the joints that affects the surrounding tissues. MicroRNAs (miRNAs) have emerged as critical regulators in OA pathophysiology, including inflammatory processes and proliferation. This study aims to investigate the link involving miRNAs and OA. Methods: A systematic search was performed employing databases such as PubMed, Scopus, EBSCO, EMBASE, and Cochrane. This research emphasizes randomized controlled trials (RCTs) and quasi-randomized controlled investigations. Data were examined using established parameters, and the integrity of research was rated using National Institutes of Health (NIH) guidelines. Results: Three RCT publications were selected for miRNA expression patterns from the 677 publications examined. This research focused on miR-140 and miR- 146, which play substantial functions in cartilage health and OA development. Conclusion: miR-140 and miR-146 have the potential to be used as a biomarker for OA.