THE ROLE OF RESVERATROL ON TGF BETA AND MMP-2 EXPRESSION IN ANIMAL MODELS OF FORM DEPRIVATION MYOPIA: LITERATURE REVIEW

Abstract

The immune system causes inflammation to draw prostaglandins, cytokines, blood cells, and cytotoxic factors, also growth factors to the infection or injury. Like myopia, this response causes local metabolic changes and tissue remodelling. TGF-β and MMP-2 increase whereas collagen (COL)1 decreases in myopic eyes. This suggests that inflammation may cause myopia. In induced myopia, topical resveratrol (RSV) boosts RPE layer effectiveness through NF-κB signalling transduction, resulting in anti-inflammatory effects and MMP-2 and TGF-β inhibition. Many medication administration strategies have been examined, including subconjunctival injection, which penetrates the posterior sclera and deposits the active material in the RPE. Few studies have examined the effects of subconjunctival resveratrol injection on MMP-2 and TGF-β in animal models of form deprivation myopia (FDM). To better understand resveratrol as anti-inflammatory in scleral remodelling, researchers will study the impact of resveratrol on MMP-2 and TGF-β expression in rabbits with form-deprivation-induced myopia.