VITAMIN B-6 DECREASES THE INCIDENCE OF POST LAPAROTOMY INTRAPERITONEAL ADHESIONS IN WISTAR RATS

Abstract

Introduction: Despite the high prevalence and morbidity of intraperitoneal adhesions, there are no promising preventive agents to prevent adhesions. The pathogenetic basis of adhesions including inflammatory pathways, fibrinolysis, and oxidative stress provides an opportunity for the role of vitamin B6 as a preventive agent.
Objectives: This study assessed the effect of intramuscular vitamin B6 administration in the prevention of post laparotomy intraperitoneal adhesions.
Methods: This study was an experimental study with Randomized Post-test only Control Group Design, in each 10 wistar rats in the treatment and control groups. All rats were subjected to laparotomy and cecum abrasion. The treatment group received intramuscular injection of vitamin B6 10 mg/kgBB/day and the control group did not receive any injection. After 6 days, relaparotomy was performed. Determination of intraperitoneal adhesion was done based on Zuhkle Criteria. Data were collected and analysed using SPSS 26.
Results: Out of 20 samples, 13 rats had intraperitoneal adhesions, and 7 rats had no adhesions. A total of 30% of the rats in the treatment group had adhesions, much less than the control group which had 100% adhesion incidence. (HR 3.3 IK 95% (1.29-8.59), p: 0.002)
Conclusions: Vitamin B6 is a preventive agent for intraperitoneal adhesions after laparotomy. Further research through clinical trials is needed before it is applied to clinical practice.