ANALYSIS OF GLOMERULAR FILTRATION RATE IN NON-ALBUMINURIC AND ALBUMINURIC TYPE 2 DIABETES MELLITUS IN EARLY DETECTION OF CHRONIC KIDNEY DISEASE

Abstract

Introduction: Chronic Kidney Disease (CKD) is a frequent complication of Type 2 Diabetes Mellitus (T2DM) and is generally tracked through albuminuria and glomerular filtration rate (GFR). Although albuminuria is a widely recognized indicator of CKD, its absence does not necessarily exclude the possibility of kidney dysfunction.
Objectives: To compare the GFR between non-albuminuric and albuminuric patients with T2DM and to evaluate the effectiveness of GFR measurement in the early detection of CKD in T2DM patients.
Methods: A prospective cross-sectional study was conducted in V.M.K.V. MEDICAL COLLEGE HOSPITAL, Department of General Medicine, between October 2023 and July 2024. The study included 100 consecutive patients with diabetes mellitus attending the OPD. Laboratory investigations were done, such as serum urea, serum creatinine, HbA1c, serum albumin, FBS, PPBS, hemoglobin, urine routine, and lipid profile.
Results: The mean age group of Non-albuminuric DM patients was 55.4±11.38 years and for Albuminuric DM patients was 53.64±10.82 years, in both the groups males were predominate with 74.0% and 78.0% in Non-albuminuric and albuminuric patients. The Prevalence of impaired GFR among the study subjects was found to be 39.0%. The Estimated GFR in mL/min per 1.73 m2 of the study subjects was found to be > 60 in 61.0% of patients followed by 30-59 (26.0), 15-29 (11.0), and <15 in 2.0% of patients.
Conclusion: The Present study results found the necessity for regular monitoring of renal function and urinary albumin levels in diabetic patients, as early identification of albuminuria can facilitate timely interventions to slow the progression of kidney disease.