SYNTHESIS, CHARACTERIZATION AND ANTI-BACTERIAL ACTIVITY OF NOVEL 1-(3-AMINOPHENYL)-3-ETHYLTHIOUREA

Abstract

BThiourea derivatives exhibit promise antibacterial action among other heterocyclic compounds in medical chemistry. Novel compound 1-(3-aminophenyl)-3-ethylthiourea synthesized by condensation of 3-chloroaniline and ethylthiourea which was demonstrated promising anti-bacterial activity. The minimum inhibitory concentration (MIC) of novel thioureas compound 1-(3-Aminophenyl)-3-Ethylthiourea was determined and before the antibacterial activity had been examined in vitro using the disk diffusion assay against gram-positive as well as gram-negative bacterias. Compound exhibited the most potent antibacterial activity against S. Aureus, E Coil, S. Aeruginosa, M. Tuberculosis and least against E. Faecalis bacteria. In this research work screening of novel thiourea compound tested against harmful bacteria.