Design, Development & Characterization of Mucoadhesive Oral Patch Loaded with Sunitinib

Abstract

The aim of the present work was to overcome the limitations of the drug and give it in form of buccal patch for better release and absorption. The first problem Solid dispersion technique was used to overcome the poor solubility of Sunitinib and it was published in a reputed online journal. 10 mucoadhesive patch were prepared by solvent casting with Sunitinib solid dispersion. The prepared patches were evaluated for weight variation, thickness, folding endurance, content uniformity, density of film, determination of % yield, surface pH, swelling index, measurement of bio-adhesive strength, in-vitro permeation. All parameters in range are shown in the formulation code TF3. The best fit for the first order release was exhibited by all of the formulations. The results show that mucoadhesive patches are better than sunitinib for enhanced drug release.