Synergistic Spectrophotometric strategies for precise Sartans quantification in Pharmaceuticals: Unifying UV Derivative and AUC approaches with solvent consistency

Abstract

This study aims to develop and validate a Ultra violet spectroscopic analytical method for accurately measuring Olmesartan Medoxomil (OLM), Telmisartan (TEL), and Valsartan (VAL), three common antihypertensive drugs. These medications block angiotensin II at the AT1 receptor, reducing blood pressure through vasodilation and decreased water retention. UV spectrophotometry offers a simple and cost-effective approach for drug quantification. The objective is to establish specific wavelengths for each drug and evaluate derivative and AUC techniques for precise measurement. A diluent of 0.1N sodium hydroxide and distilled water (3:7) was used, yielding wavelengths of 248 nm for OLM, 295 nm for TEL, and 250 nm for VAL in zero-order analysis. First-order derivative peaks were identified at 264 nm, 284 nm, and 267 nm, while second-order derivatives showed 252 nm, 241 nm, and 239 nm for OLM, TEL, and VAL, respectively. AUC analysis further refined ranges for each compound. The method was validated for accuracy, precision, sensitivity, and detection limits using this solvent system. Results demonstrated that the UV spectrophotometric method was effective for the precise quantification of OLM, TEL, and VAL. The common solvent system ensured efficiency in routine quality control. In pharmaceutical settings, this approach offers a dependable, rapid, and economical technique for monitoring these drugs.