Neuroprotective effects of Boswellia serrata extract in Huntington’s disease: Antioxidant and anti-inflammatory mechanisms in Wistar rats

Abstract

Using in vitro and in vivo rat models, the present study examined the phytochemical content and neuroprotective potential of Boswellia serrata extract in reducing the symptoms of Huntington's disease (HD) through its anti-inflammatory and antioxidant qualities.
For this study, eight Wistar rats per group received oral dosages of Boswellia serrata extract at 100, 200, and 400 mg/kg for 14 days. 3-nitropropionic acid (10 mg/kg/day, intraperitoneally) was used for two weeks to develop Huntington's disease. Antioxidant activity was measured using DPPH, ABTS, and reducing power assays. Neuroprotection was evaluated through histopathological analysis, behavioral testing, and assessment of oxidative stress markers.
Phytochemical analysis revealed high levels of acetyl-11-keto-β-boswellic acid (AKBA) in Boswellia serrata and its interaction with multiple HD-associated molecular targets. The extract showed strong antioxidant and anti-inflammatory properties by lowering lipid peroxidation, nitrite levels, and pro-inflammatory cytokines. In 3NP-induced HD models, Boswellia serrata significantly improved motor function, restored oxidative balance, and preserved neuronal architecture, indicating its efficacy in mitigating HD progression.
The extract from Boswellia serrata leaves has strong neuroprotective effects due to its anti-inflammatory and antioxidant properties. These results underline its potential as a therapeutic drug and call for more research into its molecular processes and therapeutic uses