‘Importance of Apparent Diffusion Cofficient of prostate cancer in mpMRI and correlation with Gleasons score’

Abstract

Back ground: The Gleason score is a crucial factor in assessing prostate cancer. It provides valuable information about the aggressiveness of the cancer based on its microscopic appearance. The Gleason score is assigned by a pathologist after examining prostate biopsy samples under a microscope. It ranges from 6 to 10, with higher scores indicating more aggressive cancer. This Study have explored the relationship between Gleason score and Apparent Diffusion Coefficient.
Aims & Objective: prospective analysis of mpMRI images and relevant clinical data from patient with prostate disease. The differences in ADC between different GS group were compared,and the efficacy of ADC in PCa diagnosis were analysed.. .
Method: This study was conducted on 36 prostate cancer patient who undergo mpMRI exam followed by radical prostatectomy from certain period. ADC maps were calculated with monoexponential fitting per voxel of DW images at various b value and T-test /ANOVA was used to compare the means of continuous variables like ADC value between different Gleason’s score.
Result: Significant correlations between MR imaging and tissue components were found at region-based analysis using linear mixed-effects models for all ROIs (PZ and TZ ROIs). The lumen and stroma density was positively correlated with the normalized T2-weighted MR imaging signal intensity and ADC, while the epithelium and epithelial nucleus density was negatively correlated (P,.01).
Conclusion: Significant correlations were observed between MR imaging parameters ADC and tissue components. Higher ADC positively correlated with benign tissue features (lumen and stroma) and negatively correlated with cancerous components (epithelium and epithelial nucleus).