SYNTHETIC APPROACHES OF ISATIN DERIVATIVES AS AN ANTI-CANCER AGENT

Abstract

Isatin (1H-Indole-2,3-dione) and its derivatives are an important class of Heterocyclic compounds and are majorly used as a Precursor for drug Synthesis. Since its discovery, so many research work has been done for synthesis, chemical & biological activity, and also its industrial applications. In this, we have reported several novel derivatives of N-, C-2 & C-3 substituted isatin For pharmacological activity. Here, in this study modification at C-2 and/ or C-3 carbonyl functionalities, leads to novel isatin derivatives as an anticancer activity. N- substituted novel derivatives are effective inhibitors of Carbonic anhydrase isoform IX, the form which is found to be over-expressed in a large number of solid tumors. Here also A wide range of C3-substituted isatins, like thiosemicarbazones, oxindoles, and their derivatives, imines, and hydrazones, have been synthesized. We have also summarized some recently reported biological activities exhibited by isatin derivatives, anticancer, anti-bacterial, anti-diabetic, and others. Special attention has been paid to their anti-cancer activity, and various anti-cancer targets such as histone deacetylase, carbonic anhydrase, tyrosine kinase, and tubulin against a variety of human cancer cell lines have been discussed in detail.