FORMULATION AND EVALUATION OF PREDNISOLONE ACETATE MICRO EMULSIONS

Abstract

The present study aims to formulate and evaluate a microemulsion-based drug delivery system for Prednisolone acetate, a poorly water-soluble corticosteroid. The microemulsion system is designed to enhance the solubility, stability, and bioavailability of the drug for potential usage.
Methods:
Microemulsions were prepared using oil, surfactant and co-surfactant. The formulations were optimized using pseudo-ternary phase diagrams to identify the most stable composition. The prepared microemulsions were evaluated for physicochemical properties, viscosity, pH, and drug content. In vitro drug release was studied using a dialysis membrane, and kinetic modeling was applied to determine the release mechanism.
Results:
The optimized microemulsion formulation exhibited a transparent appearance, droplet size (295 nm), PDI (0.103), and zeta potential (-43mV), indicating stability. Drug content was found to be above 95%, with a controlled drug release profile suggesting a diffusion-based release mechanism.
Conclusion:
The formulated Prednisolone acetate microemulsion showed enhanced solubility, stability, and controlled drug release, making it a promising nanocarrier for improved drug delivery. This study highlights the potential of microemulsion technology in enhancing the therapeutic efficacy of poorly soluble drugs.