In VitroAntioxidant and Anti-Inflammatory Potential of Essential Oils of Ocimum tenuiflorum And Ocimum kilimandscharicum

Abstract

Deeply ingrained in traditional Indian medical systems such as Ayurveda, Siddha and Unani along with Tibetan and Chinese medicine, medicinal plants are extremely valuable in both conventional and contemporary pharmaceuticals. For the millions of people who depend on them, they offer substantial health advantages and have a variety of therapeutic uses. Essential oils are volatile substances that are taken from aromatic and therapeutic plants. Because of their intricate chemical makeup, essential oils have been shown to have anti-inflammatory and antioxidant prospective. Their major component’s activities or interactions with one another, which are crucial in expressing their bioactive qualities, provide the basis of these activities. Analyzing antioxidant along with anti-inflammatory activities from essential oils derived out of Ocimum tenuiflorum as well as Ocimum kilimandscharicum was the aim of the present research. Using the DPPH, ABTS along with FRAP techniques, O. tenuiflorum essential oil's IC50 was 30.94±0.10μgml-1, 33.13±0.06μgml-1 and 84.51±0.86μgml-1, whereas IC50 of O. kilimandscharicum essential oil was 28.76±0.05μgml-1, 31.05±0.16μgml-1 and 68.57±0.95μgml-1, respectively. O. tenuiflorum essential oil IC50 was determined as 31.32±0.18μg ml-1 and 30.98±0.07μg ml-1 with egg albumin denaturation and proteinase inhibitory activity respectively. In contrast, the egg albumin denaturation procedure yielded IC50 27.63±0.54μg ml-1 for essential oil of O. kilimandscharicum and 26.10±0.16μg ml-1 as assessed by proteinase inhibitory activity. O. kilimandscharicum essential oil showed slightly higher anti-inflammatory and antioxidant potential as compared to O. tenuiflorum. The present investigation's conclusion is that O. tenuiflorum as well O. kilimandscharicum essential oils can be employed as sources of antioxidants and non-toxic anti-inflammatory drugs.