Graft Uptake and Hearing Outcomes in Myringoplasty by Conventional Temporalis Fascia Underlay Technique with and without Addition of Platelet Rich Fibrin (Prf): A Prospective, Randomised Double Blind Study

Abstract

Myringoplasty is a crucial surgical technique employed to repair tympanic membrane perforations, safeguarding the middle ear cavity from external exposure and associated risks. While traditional graft materials such as temporalis fascia, cartilage, and vein grafts have shown graft uptake success rates ranging from 64% to 96%, challenges like graft failure persist. To address this, innovative methods such as the application of platelet-rich fibrin (PRF) have gained attention. PRF, a second-generation platelet concentrate, is rich in growth factors, cytokines, and glycoproteins, promoting accelerated wound healing, cellular proliferation, and matrix remodelling. As an autologous material, PRF offers significant advantages, including safety, cost-effectiveness, and ease of preparation. This study aims to evaluate the efficacy of PRF in enhancing graft uptake and hearing outcomes among patients undergoing myringoplasty. By exploring its potential, this research seeks to establish PRF as an ideal adjunct in surgical management, addressing current limitations and optimizing patient care outcomes.