DESIGN AND DEVELOPMENT OF SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM FOR COMBINATION OF FELBINAC WITH ISOLATED COMPOUND

Abstract

Self-The present investigation was aimed to develop self-micro emulsifying drug delivery system microemulsifying(SMEDDS) of the felbinac and beta sitosterol as isolated compound. SMEDDS is one of the drug deliverypromising approach for the delivery of both the hydrophobic as well as hydrophilic drug. In systems, Felbinac,the present research work Felbinac and beta sterol help in the reduction of inflammation and Composition, anti-pain. . Ternary phase diagrams (Sigma plot) were constructed in order to obtain the most inflammatory gel,efficient self-emulsification region, and the formulation of both the drug loaded SMEDDS was Oral Bioavailability.optimized by a pseudo ternary phase diagram. The S:Cos ratio 2:1 was show the larger than the other ratio 1:1 and 3:1 Tween 20 taken as surfactant, propylene glycol taken as cosurfactant and as oil virgin coconut oil were used for SMEDDS formulation by titration method. With the help of Box-behnken design (Statease software) the ratio formulation was optimized and this was developed into gel. SMEDDS was evaluated and compared with gel SMEDDS.