Design AND Evaluation OF Floating Drug Delivery System OF AN Nelfinavir MESYLATE Antiviral Drug USING Different Natural Polymers

Authors

  • Mohan Koteswara Rao Sandu, Beduin Mahanti, Shaik Harun Rasheed

DOI:

https://doi.org/10.70135/seejph.vi.6854

Abstract

In the present study, an attempt was made to formulate floating tablets of Nelfinavir mesylate by various synthetic and natural polymers by direct compression method to increase the gastric retention time of the drug and thus increases the bioavailability of the drug. Optimized formulations NFS4 utilized HPMC K4M and NFB3 used Bhara gum this led to prolonged retention in the gastric area, minimizing fluctuations in plasma concentration that often occur with conventional dosage forms. Among the natural polymers, Bhara gum performed exceptionally well, with NFB3 exhibiting the shortest lag time of 1.33 min. These formulations were further evaluated for stability and in vivo studies. Floating drug delivery systems offer significant future potential, including reducing fluctuations in drug plasma levels due to delayed gastric emptying and decreasing the need for frequent drug administration.

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Published

2025-01-25

How to Cite

Mohan Koteswara Rao Sandu, Beduin Mahanti, Shaik Harun Rasheed. (2025). Design AND Evaluation OF Floating Drug Delivery System OF AN Nelfinavir MESYLATE Antiviral Drug USING Different Natural Polymers. South Eastern European Journal of Public Health, 4435–4454. https://doi.org/10.70135/seejph.vi.6854

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Articles